南科大化学系本科生在《德国应用化学》发表论文 近日,我校化学系本科生陈伟豪(第一作者,我校13级本科生,2017年毕业)及陈阳(我校15级本科生)在国际顶尖化学期刊《德国应用化学》(Angew. Chem. Int. Ed.)上发表论文。
张绪穆课题组在《美国化学会志》发表论文 近日,我校化学系讲座教授张绪穆课题组在国际顶尖化学期刊《美国化学会志》 (J. Am. Chem. Soc., IF = 13.858)上发表简单酮高效、高选择性不对称还原胺化论文。
何凤课题组在《自然通讯》上发表重要研究成果 近日,我校化学系副教授何凤课题组在聚合物二维超分子自组装领域上取得重要研究进展,该成果发表在著名国际期刊《Nature Communications》(影响因子12.124)
徐晶课题组在《德国应用化学》发表VIP论文 该论文同时被该期刊选为VIP(Very Important Paper)与封底论文(Back Cover)。恰逢中国春节,该封底设计为中国传统窗花形式,嵌入Astellatol分子三维结构、福字和南科大Logo,充满节日喜庆气氛。
致敬时代深士:化学系主任张绪穆获此殊荣 本次评选,共有82家政府部门、社会机构、行业协会、代表企业等参与推举,经过评委会的慎重票选和网络上近200万人次的投票,最终诞生6名“2016时代深士”。
许宗祥课题组在钙钛矿太阳电池空穴传输材料取得进展 论文在Nano Energy(IF=11.553)在线发表。论文详细介绍了新型金属酞菁功能材料分子设计与太阳电池器件应用研究的成果。
蒋伟课题组发明检测地下水中持久性污染物简易方法 我校化学系蒋伟课题组提出了地下水中持久性污染物——1,4-二氧六环的简便检测方法。该研究成果在线发表在化学类顶级期刊JACS上(IF=13.038)。

谭斌

教授

化学系

0755-88018315

tanb@sustc.edu.cn

研究方向
​核心骨架结构导向的催化不对称合成 等

谭斌教授,化学系副主任、博士生导师、国家千人计划青年专家。2001年本科毕业于湖南科技大学;2005年硕士毕业于厦门大学化学系。 2006年开始在新加坡南洋理工大学化学与生物化学系钟国富教授的指导下从事新型手性有机催化剂的设计及不对称多米诺反应的研究,于2010 3月获得博士学位。20103月至2012 9月,有幸在有机小分子催化领域的发源地--美国斯克普斯研究所 The Scripps Research Institute),师从Barbas教授继续在此领域从事博士后研究。20129月以准聘(Tenure-Track)副教授身份加入南方科技大学化学系,20181月晋升为终身正教授。

到目前为止,在轴手性化学、核心骨架导向的不对称催化、自由基化学以及协同催化领域发表高水平研究论文60多篇,以第一作者或通讯作者身份已经发表包括2Nature Chemistry、3Nature Communications 6J. Am. Chem. Soc.11Angew. Chem. Int. Ed. 1Accounts of Chemical Research,总被引次数超过3000次。多篇论文被多篇文章被不同国际杂志重点评述或被选为封面文章。此外还有多篇高水平研究论文正在审稿和准备之中。


2012年,中组部第四批“青年千人计划”入选者

2013年,深圳市海外高层次人才“孔雀计划”B类入选者

◆ 核心骨架结构导向的催化不对称合成    

◆ 有机催化不对称多组分反应

◆ 金属与有机催化协同的催化体系应用   

◆ 手性药物的开发和天然产物策略全合成

1.    国家“青年千人计划“研究基金+广东省配套经费(250万);

2.    孔雀计划配套科研启动经费(500 + 100 )

核心骨架结构导向的催化不对称合成;

3.    国家自然科学基金委面上项目(80万)

有机催化不对称合成联芳基轴手性化合物;

4.    国家自然科学基金委青年基金项目(25)

不对称合成具有重要生物活性3,3′-四氢吡咯螺羟吲哚骨架结构;

5.    深圳市科技创新委员会基础研究项目(10万)

四氢吡咯螺羟吲哚衍生物的设计和催化不对称合成以及抗癌活性的研究;

6.    深圳市科技创新委员会基础研究项目(30万)

基于重氮吲哚酮的催化不对称合成及其产物的抗癌活性研究;

7.    深圳市科技创新委员会“孔雀团队”项目(200万)

重大药物的绿色制备

a代表性研究成果:(独立工作以前)


1.  Tan, B.; Candeias, N.; Barbas III, C. F. Construction of Bispirooxindoles Containing three Quaternary Stereocentres in a Cascade Using a Single Multifunctional Organocatalyst. Nature Chem. 2011, 3, 473-477.

2.  Tan. B.; Toda N; Barbas III, C. F. Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-coupling Strategy. Angew. Chem. Int. Ed. 2012, 51, 12538-12541.

3.  Tan. B.; Hernández-Torres, G.; Barbas III, C. F. Rational Design Enables Amide Nucleophiles for Organocatalytic Asymmetric Michael Reactions. Angew. Chem. Int. Ed. 2012, 51, 5381-5385.

4.  Tan B.; Hernández-Torres, G.; Barbas III, C. F. Highly Efficient Hydrogen-Bonding Catalysis of the Diels-Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeleton. J. Am. Chem. Soc. 2011, 131, 12354-12358.

5.  Tan, B.; Candeias, N.; Barbas III, C. F. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. J. Am. Chem. Soc. 2011, 131, 4672-4675.

6.  Tan, B.; Shi. Z.; Chua, P. J.; Li, Y.; Zhong, G. Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles. Angew. Chem. Int. Ed. 2009, 48, 758-761.

 

代表性研究成果:(独立工作以后从20138月至今)

1. Yong-Bin Wang, Bin Tan*. Construction of Axially Chiral Compounds via Asymmetric Organocatalysis. Acc. Chem. Res. 2018, 51, in press.

2. Liang-Wen Qi,# Jian-Hui Mao,# Jian Zhang, Bin Tan*. Organocatalytic Asymmetric Arylation of Indoles Enabled by Azo Groups. . Nat. Chem. 2018, 10, 58. ( # equal contribution)

3. Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu, Bin Tan*. Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones. Nat. Commun. 2017, 8, 15489.

4. Sheng-Cai Zheng, San Wu, Yun-Hao Zhang, Liu Ye, Bin Tan*. Organocatalytic atropselective synthesis of axially chiral styrenes. Nat. Commun. 2017, 8, 15238.

5. Lei Zhang, Jian Zhang, Ji Ma, Dao-Juan Cheng, Bin Tan*. Brønsted acid-catalyzed atropselective Paal-Knorr reaction. J. Am. Chem. Soc. 2017, 139, 1714.

6. Ye-Hui Chen, Liang-Wen Qi, Fang Fang, Bin Tan.* Organocatalytic Atroposelective Arylation of 2-Naphthylamines as a Practical Approach to Axially Chiral Biaryl Amino Alcohols. Angew. Chem. Int. Ed. 2017, 56, 16308.

7. Shaoyu Li, Ji-Wei Zhang, Xian-Lin Li, Bin Tan*. Phosphoric acid-catalyzed atroposelective synthesis of SPINOL derivatives. J. Am. Chem. Soc. 2016, 138, 16561.

8. Jin-Hui Xu, Sheng-Cai. Zheng, Ji-Wei Zhang, Xin-Yuan Liu, Bin Tan*. Organocatalytic asymmetric dearomatization of iIsoquinolines enables construction of tropane derivatives. Angew. Chem. Int. Ed. 2016, 55, 11834.

9. Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu* and Bin Tan*. Discovery and Enantiocontrol of Axially Chiral Urazoles via Organocatalytic Tyrosine Click Reaction. Nat. Commun. 2016, 7, 10677.

10. Ye-Hui Chen, Dao-Juan Cheng, Jian Zhang, Yong Wang, Xin-Yuan Liu*, and Bin Tan*. Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2‑Naphthols. J. Am. Chem. Soc. 2015, 137, 15062.

11. Jian Zhang,# Shao-Xia Lin,# Dao-Juan Cheng, Xin-Yuan Liu,* and Bin Tan*. Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction. J. Am. Chem. Soc. 2015137, 14039. ( # equal contribution)

12. Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan*. Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles. Angew. Chem. Int. Ed. 201554, 9409.

13. Zhi-Jia Fang,# Sheng-Cai Zheng,# Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*. Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation. Angew. Chem. Int. Ed. 2015, 54, 9528. ( # equal contribution)

14. Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*. Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of  Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 201554, 7847.

15. Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*. Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 201554, 4041.

16. Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu*. Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene. Angew. Chem. Int. Ed. 2014, 5311890.

17. Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan*. Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid. Angew. Chem. Int. Ed. 2014, 53, 3684.

18. Lin Huang, Jin-Shun Lin, Bin Tan,* and Xin-Yuan Liu*. Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 20155, 2826.

19. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 201517, 1589-1592.

20. Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds. Chem. Eur. J. 201521, 6718.

21. Lei Li, Jing-Yao Guo, Su Chen, Tao Wang, Bin Tan* and Xin-Yuan Liu* “Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation” Org. Lett.,201416, 6032.

22. Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan* and Xin-Yuan Liu* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles” J. Org. Chem. 2014, 79, 7084.

23. Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu* and Bin Tan* “In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles” Org. Lett. 201416, 2192.

24. Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu* “Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement” Org. Lett. 201416, 1000.

25. Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan* and Xin-Yuan Liu.* “Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles” Org. Lett. 2014, 16, 504.

26. Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles” Chem. Eur. J. 201420, 1332.

27. Dao-Juan Cheng, Yoshihiro Ishihara, Bin Tan* and Carlos F. Barbas, III*. Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies. ACS Catal. 20144, 743.


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